Amifostine manufacturers and suppliers in india

Amifostine

Properties

Melting point:: 160-1610C

Boiling point:: 441.7±51.0 °C(Predicted)

Density: 1.367±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Soluble in Water.

form: powder

pka: 1.28±0.10(Predicted)

color: White

Water Solubility: Soluble to 100 mM in water

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P330-P501

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: TE6491000

Toxicity: cyt-mus-ipr 300 mg/kg CUSCAM 54,1080,85

Use

Amifostine, an organic thiophosphate, was introduced for the reduction of cisplatin-induced renal toxicity in patients with advanced ovarian cancer. It is also a radio-protective agent. Amifostine is a prodrug which is rapidly dephosphorylated, preferentially in non-tumor tissues to the active thiol. This agent binds to chemotherapeutic drugs and free radicals released by radiotherapy. The protective effect of amifostine was observed in a wide range of normal organs including bone marrow and gastrointestinal mucosa without interfering with the anti-tumor effect of chemohadiotherapy, indicating an increased therapeutic index for existing cancer treatment. Amifostine is also being evaluated as a cytoprotective in other types of tumors including lung, breast, head and neck cancers. It was reported to be a potent mucolytic with potential in cystic fibrosis.