ANISOMYCIN manufacturers and suppliers in india

ANISOMYCIN

Properties

Melting point:: 140-141 C

Boiling point:: 408.52°C (rough estimate)

alpha: D23 -30° (methanol)

Density: 1.1356 (rough estimate)

refractive index: 1.5230 (estimate)

Flash point:: 87℃

storage temp.: Inert atmosphere,Store in freezer, under -20°C

solubility: methanol: 20 mg/mL, clear, colorless to faintly yellow

form: solid

pka: 7.9(at 25℃)

color: white

Water Solubility: Soluble in water at 2 mg/ml, in DMSO at 20mg/ml, and in methanol at 20mg/ml

λmax: 283nm(EtOH)(lit.)

Merck: 14,670

BRN: 20705

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: YKJYKKNCCRKFSL-RDBSUJKOSA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P405-P501

Hazard Codes: T,Xn

Risk Statements: 25-36/37/38-20/21/22

Safety Statements: 45-36-26

RIDADR: UN 3462 6.1/PG 3

WGK Germany: 3

RTECS: BZ9800000

F: 3-10

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29419090

Toxicity: LD50 orl-rat: 72 mg/kg ANTCAO 5,490,55

Use

Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells.