ascochlorin
ascochlorin
- CAS:
- 26166-39-2
- MF:
- C23H29ClO4
- MW:
- 404.931
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Company Type
Properties
- Melting point:
- 172-174 °C
- Boiling point:
- 556.9±39.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- A powder
- pka
- 6.26±0.50(Predicted)
Safety Information
- WGK Germany
- 3
- Toxicity
- mouse,LD50,intraperitoneal,20mg/kg (20mg/kg),Journal of Antibiotics. Vol. 21, Pg. 539, 1968.
Use
Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 μM) by inhibiting the expression of matrix metalloproteinase-9. At 2 μM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 μm, it inhibits signaling through STAT3. Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.[Cayman Chemical]
0 India supplier list of "ascochlorin"
- Product Name:Ascochlorin
- Products Intro:Brand:clearsynth | Product Number:CS-CM-00017
- Company Type: Trader
- Country/Region: INDIA
-
5mg$970.00
- Product Name:Ascochlorin
- Products Intro:Brand:TargetMol | Product Number:T14330 | Purity:98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Ascochlorin
- Products Intro:Purity: >98% | CustNote: BOC Sciences also provides custom synthesis services for Ascochlorin.
- Company Type: Reagent
- Country/Region: UNITED STATES
- Product Name:Ascochlorin
- Products Intro:Purity: NLT 98% | CustNote: MC545084
- Company Type: Manufacturer
- Country/Region: CHINA
- Product Name:Ascochlorin
- Products Intro:Purity: >95% | Package: $341.9/500μg;Bulk package | CustNote: >95%
- Company Type: Trader
- Country/Region: UNITED STATES
-
500ug$326.00
- Product Name:Ascochlorin
- Products Intro:Brand: Sigma-Aldrich | Product Number: SML0104 | Purity: ≥98% (HPLC), from Verticillium hemipterigenum
- Company Type: Trader
- Country/Region: UNITED STATES
-
500 µg$236.00
- Product Name:Ascochlorin
- Products Intro:Brand：Caymanchem | Product Number：19437 | Purity：≥98%
- Company Type: Trader
- Country/Region: UNITED STATES
-
2.5mg$1608.00
- Products Intro:Brand:1pchem | Product Number:1P00BIYP | Purity:≥98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:5-Chloro-2,4-dihydroxy-6-methyl-3-[(2E,4E)-3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)penta-2,4-dienyl]benzaldehyde
- Products Intro:Brand：aksci | Product Number：0615CP
- Company Type: Trader
- Country/Region: UNITED STATES
-
2.5mg$3410.00
- Product Name:Ascochlorin
- Products Intro:Brand:trc-canada | Product Number:A787028
- Company Type: Trader
- Country/Region: CANADA