AT9283
AT9283
- CAS:
- 896466-04-9
- MF:
- C19H23N7O2
- MW:
- 381.43
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Company Type
Properties
- Density
- 1.45
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 10.58±0.10(Predicted)
- color
- White to off-white
Safety Information
Use
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]
1 India supplier list of "AT9283"
- Product Name:AT9283 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089082
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:AT9283
- Products Intro:Brand:ajchemicals | Product Number:JDH-26396 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:AT9283
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:AT9283
- Products Intro:Purity: >98% | Package: 10mg | CustNote: BOC Sciences also provides custom synthesis services for AT9283.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:AT9283
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1h-benzo(d)imidazol-2-yl)-1h-pyrazol-4-yl)urea
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:AT9283 AKSci SYN1011 AT-9283
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: AT9283
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:At9283
- Products Intro:CustNote: https://www.alfa-chemistry.com/at9283-cas-896466-04-9-item-294020.htm
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Active Pharmaceutical Ingredient (API),Insect Pheromone,Boronic Compounds,Material & Chemicals,Lipid Compounds
- Product Name:AT-9283
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks