Bestatin manufacturers and suppliers in india

Bestatin

Properties

Melting point:: 245 °C (dec.)(lit.)

alpha: D20 -15.5° (c = 1.0 in 1N HCl)

Boiling point:: 448.76°C (rough estimate)

Density: 1.0917 (rough estimate)

refractive index: 1.5800 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: Aqueous Acid (Slightly, Sonicated), DMSO (Slightly, Heated)

pka: 8.1, 3.1(at 25℃)

form: Powder

color: White

optical activity: [α]20/D 11°, c = 1 in 1 M NaOH

Water Solubility: Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Merck: 13,9910

InChIKey: VGGGPCQERPFHOB-RDBSUJKOSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Safety Statements: 22-24/25

WGK Germany: 3

RTECS: OH2915000

HS Code: 29242998

Toxicity: LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara)

Use

Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.