Bleomycin
Bleomycin
- CAS:
- 11056-06-7
- MF:
- C110H168N34O46S7
- MW:
- 2927.17
Suppliers by country/region
Company Type
Properties
- storage temp.
- 2-8°C
- solubility
- H2O: 20 mg/mL
- form
- powder
- color
- white
Safety Information
- Hazard Codes
- T
- Risk Statements
- 46-40
- Safety Statements
- 53-36/37-45
- WGK Germany
- 3
- RTECS
- EC5991990
- F
- 10
- Toxicity
- dog,LD,oral,> 100mg/kg (100mg/kg),Japanese Journal of Antibiotics. Vol. 28, Pg. 1, 1975.
Use
Bleomycin is a glycopeptide antibiotic complex isolatedfrom Streptomyces verticillus initially by Umezawa.Atleast 13 different fractions of bleomycin have been isolatedwith the clinically used product (Blenoxane) being a mixtureof predominantly A22 (55%–70%) and B2 (25%–32%)fractions.Of these fractions, A2 appears to possessthe greatest antineoplastic activity. Copper is found inthe naturally occurring material, and its removal is importantfor the material used clinically because it significantlyreduces activity.Bleomycin is notable for its lack of myelotoxicity, andthis allows it to be combined with other myelosuppressantswithout a resulting additive effect. The acute toxicities seenwith bleomycin are erythema (reddening of the skin), hyperpigmentation(skin darkening) found predominately on theextremities, and pulmonary toxicity. The pulmonary toxicitymay first occur as pneumonitis (inflammation of lung tissue),which normally responds to glucocorticosteroid therapy.Chronic pulmonary toxicity is expressed as pulmonaryfibrosis, which is irreversible and limits utility of the agent.
3 India supplier list of "Bleomycin"
- Product Name:Bleomycin
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Bleomycin
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Bleomycin
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:Bleomycin
- Products Intro:Brand:pharmaffiliates | Product Number:PA2905000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Bleomycin
- Products Intro:Purity: 99.9% | Package: 1kg;|25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2-Chloromalonaldehyde,(R)-5,7-difluorochroman-4-ol,Cyclobutanecarboxylic acid,(Bromomethyl)cyclobutane,5-Amino-4-imidazolecarboxamide
$0.00-0.00 / 1kg
- Product Name:Bleomycin
- Products Intro:Purity: 0.98 | Package: 1kg，2kg，5kg，10kg，25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
- Product Name:bleomycin
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Bleomycin
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Gamma-butyrolactone
