Cidofovir manufacturers and suppliers in india

Cidofovir

Properties

Melting point:: 260° (dec)

alpha: D20 -97.3° (c = 0.80 in water)

Boiling point:: 609.5±65.0 °C(Predicted)

Density: 1.76±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: deionized water: ≥5mg/mL (warmed)

form: powder

pka: 2.29±0.10(Predicted)

color: White to off-white

Water Solubility: Soluble to 12 mg/mL (42.98 mM) in Water

InChI: InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1

InChIKey: VWFCHDSQECPREK-LURJTMIESA-N

SMILES: P(CO[C@H](CO)CN1C(=O)N=C(N)C=C1)(=O)(O)O

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301-H315

Precautionary statements: P301+P310+P330-P302+P352

Hazard Codes: T

Risk Statements: 25-38

Safety Statements: 36-37-45

RIDADR: UN 2811 6.1 / PGIII

WGK Germany: 3

RTECS: SZ6545000

Use

Cidofovir, (S)-3-hydroxy-2-phosphonomethoxypropyl cytosine(HPMPC, Vistide), is an acyclonucleotide analog thatpossesses broad-spectrum activity against several DNAviruses. Unlike other nucleotide analogs that are activated tonucleoside phosphates, Cidofovir is a phosphonic acid derivative.The phosphonic acid is not hydrolyzed by phosphatasesin vivo but is phosphorylated by cellular kinases to yield adiphosphate. The diphosphate acts as an antimetabolite to deoxycytosinetriphosphate (dCTP). Cidofovir diphosphate is acompetitive inhibitor of viral DNA polymerase and can beincorporated into the growing viral DNA strand, causingDNA chain termination.Cidofovir possesses a high therapeutic index against CMVand has been approved for treating CMV retinitis in patientswith AIDS. Cidofovir is administered by slow, constant intravenousinfusion in a dose of 5 mg/kg over a 1-hour periodonce a week for 2 weeks. This treatment is followed by amaintenance dose every 2 weeks.