Clioquinol
Clioquinol
- CAS:
- 130-26-7
- MF:
- C9H5ClINO
- MW:
- 305.5
Suppliers by country/region
Company Type
Properties
- Melting point:
- 175-183 °C
- Boiling point:
- 350.4±37.0 °C(Predicted)
- Density
- 1.8959 (estimate)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
- pka
- pKa 8.12(50%aqEtOH t=35.0±0.1 I=0.00 N2atmosphere)(Approximate)
- form
- Solid
- color
- Light Beige to Beige
- Water Solubility
- <0.1 g/100 mL at 20 ºC
- Merck
- 14,5031
- BRN
- 153637
- LogP
- 1.523 at 24℃
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301-H315-H317-H319
- Precautionary statements
- P261-P264-P280-P301+P310-P302+P352-P305+P351+P338
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- VC5075000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933492250
- Toxicity
- LD50 orally in cats: 400 mg/kg (Davis)
Use
Clioquinol, a halogenated hydroxyquinoline derivative, was introduced into medicine around 1900 as a topical antiseptic and in 1934 oral preparations for the treatment of amoebic dysentery and simple diarrhoea became available. By 1964 its use in Japan had been associated with cases of sub-acute myelo-optic neuropathy (SMON) which reached epidemic proportions resulting in its withdrawal there in 1970. Although relatively few cases of SMON were documented elsewhere, clioquinol was subsequently withdrawn from use in many countries and placed under prescription control in others. It was phased out worldwide by the major manufacturer between 1983 and 1985 on grounds of obsolescence. No adequately controlled evidence was ever generated to demonstrate that clioquinol is effective in bacterial or viral diarrhoea. However, products containing clioquinol and related halogenated hydroxyquinolines continue to be used in some tropical and subtropical countries where amoebiasis remains endemic. Other amoebocides are preferred in the WHO Model List of Essential Drugs. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)
40 India supplier list of "Clioquinol"
- Product Name:Clioquinol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Clioquinol
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Clioquinol
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Clioquinol
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Clioquinol
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Clioquinol-CAS130-26-7-Calbiochem
- Products Intro:Brand:sigma aldrich | Product Number:233165 | Purity:Ametalionchelatorthatcrossesthebloodbrainbarrierandactsasaneurotoxicantibiotic.
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Clioquinol
- Company Type: Reagent
- Country/Region: INDIA