Clofazimine
Clofazimine
- CAS:
- 2030-63-9
- MF:
- C27H22Cl2N4
- MW:
- 473.4
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Company Type
Properties
- Melting point:
- 210-212°
- Boiling point:
- 616.26°C (rough estimate)
- Density
- 1.1342 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, soluble in methylene chloride, very slightly soluble in ethanol (96 per cent). It shows polymorphism (5.9).
- pka
- 8.37; also reported as 8.51(at 25℃)
- form
- Solid
- color
- Yellow to Amber to Dark red
- Water Solubility
- 10mg/L(temperature not stated)
- Merck
- 14,2373
- BCS Class
- 4/3
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H335-H319-H413
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-26
- WGK Germany
- 3
- RTECS
- SG1578000
- HS Code
- 35040000
- Toxicity
- LD50 orally in mice, rats, and guinea pigs: >4 g/kg (Stenger)
Use
Clofazimine (Lamprene) is a basic red dye that exerts a slow bactericidal effect on M. leprae, the bacterium that causes leprosy. It occurs as a dark red crystalline solid that is insoluble in water. Clofazimine is used in the treatment of lepromatous leprosy, including dapsone-resistant forms of the disease. In addition to its antibacterial action, the drug appears to possess anti-inflammatory and immune-modulating effects that are of value in controlling neuritic complications and in suppressing erythema nodosum leprosum reactions associated with lepromatous leprosy. It is frequently used in combination with other drugs, such as dapsone or rifampin.
5 India supplier list of "Clofazimine"
- Product Name:Clofazimine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Clofazimine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Clofazimine
- Products Intro:Brand:sigma aldrich | Product Number:C8895
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Clofazimine
- Products Intro:Brand:synzeal | Product Number:174129049
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Clofazimine
- Products Intro:Brand:pharmaffiliates | Product Number:PA5629000
- Company Type: Trader
- Country/Region: INDIA