CYTISINE manufacturers and suppliers in india

CYTISINE

Properties

Melting point:: 154-156 °C (lit.)

Boiling point:: 218 °C/2 mmHg (lit.)

alpha: D17 -120°

Density: 1.0815 (rough estimate)

refractive index: 1.5700 (estimate)

storage temp.: Keep in dark place,Sealed in dry,2-8°C

solubility: 439g/l

pka: 6.11, 13.08(at 25℃)

form: powder

color: light yellow

optical activity: [α]/D -108±3°, c = 1% in ethanol

Water Solubility: 439g/L(16 ºC)

Merck: 14,2789

InChIKey: ANJTVLIZGCUXLD-DTWKUNHWSA-N

LogP: 0.172 (est)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301+H311+H331

Precautionary statements: P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311

Hazard Codes: T

Risk Statements: 25-36/37/38

Safety Statements: 26-28-36/37-45

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: HA4025000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29399990

Toxicity: LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod)

Use

Cytisine (also known as baptitoxine and sophorine) is a kind of naturally occurring alkaloid that can be found in several plant genera including Laburnum and Cytisus in the family Fabaceae. It has been shown that it is effective in the smoking cessation treatment. It is a low efficacy partial agonist of alpha4-beta2 nicotinic acetylcholine receptors, which is the central target of the nicotine that facilitates addiction. Cytisine is capable of reducing the effect of nicotine on dopamine release on the mesolimbic system as well as attenuating the nicotine withdrawal symptoms. Cytisine is also a useful reagent for organic chemistry such as being used for the manufacture of sparteine surrogate.