Dihydrotachysterol manufacturers and suppliers in india

Dihydrotachysterol

Properties

Melting point:: 116-120°C

alpha: D22 +97.5° (chloroform)

Boiling point:: 461.8°C (rough estimate)

Density: 0.9678 (rough estimate)

refractive index: 1.5100 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in acetone and hexane, sparingly soluble in ethanol (96 per cent).

pka: 14.96±0.40(Predicted)

form: Solid

color: White to off-white

Stability:: Light sensitive

InChIKey: ILYCWAKSDCYMBB-KWOSLRGBSA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301-H413

Precautionary statements: P264-P270-P273-P301+P310-P405-P501

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 36

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: WW0600000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 2936299055

Toxicity: LD50 oral in mouse: 288mg/kg

Use

Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1,25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. It also increases renal phosphate excretion. In contrast to parathyroid extract, dihydrotachysterol is active when taken orally, exerts a slow but persistent effect, and may be used for long periods without increasing the dosage or causing tolerance. Dihydrotachysterol is faster-acting than pharmacologic doses of vitamin D and is less persistent after cessation of treatment, thus decreasing the risk of accumulation and of hypercalcemia.