EFONIDIPINE manufacturers and suppliers in india

EFONIDIPINE

CAS:: 111011-76-8

MF:: C34H38N3O7P

MW:: 631.66

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Properties

Melting point:: 151° (dec)

storage temp.: Inert atmosphere,2-8°C

solubility: DMSO : 25 mg/mL (35.01 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)

form: Powder

color: Light yellow to yellow

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501

Use

Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca+2 uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.