Epothilone A
Epothilone A
- CAS:
- 152044-53-6
- MF:
- C26H39NO6S
- MW:
- 493.66
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Company Type
Properties
- Melting point:
- 95℃
- alpha
- D21 -47.1° (c = 1.0 in methanol)
- Boiling point:
- 683.3±55.0 °C(Predicted)
- Density
- 1.143
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- pka
- 13.57±0.70(Predicted)
- form
- solid
- color
- White to Off-White
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- InChIKey
- HESCAJZNRMSMJG-KKQRBIROSA-N
- SMILES
- [C@]12([H])[C@]([H])(O1)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(/C)=C/C1=CSC(C)=N1)C2
Safety Information
- WGK Germany
- 3
Use
Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumour agent.The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.
0 India supplier list of "Epothilone A"
- Product Name:(−)-EpothiloneA
- Products Intro:Brand:sigma aldrich | Product Number:E3656 | Purity:fromSorangiumcellulosum,>95%(HPLC),solid
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:EpothiloneA
- Products Intro:Brand:clearsynth | Product Number:CS-T-21796
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
-
100mg$500mg$1EA$
- Product Name:Epothilone A
- Products Intro:Purity: 95% | Package: 100mg;USD|500mg;USD|1EA;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Parthenolide,ACT001,Micheliolide,Costunolide,Ovatodiolide
$1.00/ 1KG
- Product Name:Epothilone A
- Products Intro:Purity: 99% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:epothilone a
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Epothilone A
- Products Intro:Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Octane booster,lubricant additve,specialty chemicals,ingredients
- Product Name:Epothilone A
- Products Intro:Purity: 99.48% | Package: 5mg;43USD|10mg;71USD|25mg;143USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:Epothilone A
- Products Intro:Purity: 99% contact email: Jessie@coreychem.com | Package: 1g;2.3USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Methyl 3-amino-2-fluorobenzoate
- Product Name:Epothilone A
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Epothilone A
- Products Intro:Purity: 98% | Package: 1g,10g,25g,100g,500g,1kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 528-94-9,AMMONIUM SALICYLATE,Linolenic acid,463-40-1,931-36-2