Ethambutol manufacturers and suppliers in india

Ethambutol

Properties

Melting point:: 199-204℃

Boiling point:: 345℃

alpha: D25 +13.7° (c = 2 in water)

Density: 1.0048 (rough estimate)

refractive index: 1.4610 (estimate)

RTECS: EL3640000

Flash point:: >110°(230°F)

storage temp.: Keep in dark place,Sealed in dry,2-8°C

solubility: Soluble in DMSO

form: Powder

pka: pKa 6.6 (H2O) (Uncertain);9.5(H3O) (Uncertain)

color: White to off-white

Water Solubility: Soluble in water. Also soluble in chloroform and methylene chloride

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312a-P330-P501a

Toxicity: LD50 oral in rat: 998mg/kg

Use

Ethambutol is active against several species of mycobacteria and nocardiae. MICs on solid media are: M. tuberculosis 0.5–2 mg/L; M. kansasii 1–4 mg/L; other slowly growing mycobacteria 2–8 mg/L; rapidly growing pathogens 2–16 mg/L; Nocardia spp. 8–32 mg/L. Resistance is uncommon and is a multistep process due to mutations in the embA, embB and embC gene cluster. A mutation in codon 306 of the embB gene predisposes to the development of resistance to a range of antituberculosis agents, possibly by affecting cell-wall permeability.