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Fenfluramine hydrochloride
Fenfluramine hydrochloride
- CAS:
- 404-82-0
- MF:
- C12H17ClF3N
- MW:
- 267.72
Properties
- Melting point:
- 1660C
- Boiling point:
- 108-112 °C(Press: 12 Torr)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
- form
- A solid
- Stability:
- Hygroscopic
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H300
- Precautionary statements
- P264-P270-P301+P310-P321-P330-P405-P501
- Hazard Codes
- T
- Risk Statements
- 25-23/24/25
- Safety Statements
- 7-16-36/37-45-36/37/39-22
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DA0295500
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 oral in rabbit: 50mg/kg
Use
Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
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