Fenfluramine hydrochloride
- CAS No.
- 404-82-0
- Chemical Name:
- Fenfluramine hydrochloride
- Synonyms
- FENFLURAMINE HCL;ponderal;ponderax;FENFLURAMINE HYDROCHLORIDE;FEBFLURAMINE HYDROCHLORIDE;phenfluoraminehydrochloride;rac Fenfluramine Hydrochloride;2H6]-Fenfluramine hydrochloride;(+/-)-FENFLURAMINE HYDROCHLORIDE;Fenfluramine hydrochloride USP/EP/BP
- CBNumber:
- CB0314194
- Molecular Formula:
- C12H17ClF3N
- Molecular Weight:
- 267.72
- MOL File:
- 404-82-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/7/9 8:28:05
| Melting point | 1660C |
|---|---|
| Boiling point | 108-112 °C(Press: 12 Torr) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | A solid |
| Stability | Hygroscopic |
| CAS DataBase Reference | 404-82-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45-36/37/39-22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DA0295500 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 oral in rabbit: 50mg/kg | |||||||||
| NFPA 704 |
|
Fenfluramine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Controlled substance. Anorexic
Definition
ChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
General Description
Fenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl
Fenfluramine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Biophore India Pharmaceuticals Pvt Ltd | +91-9100031592 +91-9030907714 | Telangana, India | 134 | 58 | Inquiry |
| VCS Chem Tech Pvt Ltd | +91-8008851342 +91-8008851342 | Telangana, India | 66 | 58 | Inquiry |
| MAITHRI DRUGS PRIVATE LTD | +91 40 30438600 | New Delhi, India | 29 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10318 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
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