FENFLURAMINE
- CAS No.
- 458-24-2
- Chemical Name:
- FENFLURAMINE
- Synonyms
- EQUINE;Acino;Pesos;S-768;C06996;Obedrex;Adipomin;Ponderex;Pondimin;Rotondin
- CBNumber:
- CB1325500
- Molecular Formula:
- C12H16F3N
- Molecular Weight:
- 231.26
- MOL File:
- 458-24-2.mol
- Modify Date:
- 2024/3/19 15:37:51
| Melting point | 170°C |
|---|---|
| Boiling point | bp12 108-112° |
| Density | 1.0950 (estimate) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | pKa 9.10 (Uncertain) |
| color | Colourless to Pale Yellow |
| Stability | Hygroscopic |
| CAS DataBase Reference | 458-24-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45 |
| Toxicity | LD50 i.p. in mice: 144 mg/kg |
FENFLURAMINE Chemical Properties,Uses,Production
Uses
Anorexic.
Definition
ChEBI: A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reu take pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding ehavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertensio .
World Health Organization (WHO)
Fenfluramine, dexfenfluramine and phentermine were approved individually more than 20 years ago in the USA for single-drug, short-term treatment of obesity. The manufacturers of fenfluramine and dexfenfluramine have since voluntarily withdrawn both products from the market worldwide. Phentermine remains available.
FENFLURAMINE Preparation Products And Raw materials
Raw materials
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