Fisetin
Fisetin
- CAS:
- 528-48-3
- MF:
- C15H10O6
- MW:
- 286.24
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Properties
- Melting point:
- >330 °C(lit.)
- Boiling point:
- 348.61°C (rough estimate)
- Density
- 1.2981 (rough estimate)
- refractive index
- 1.4413 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- Colour Index
- 75620
- pka
- 6.83±0.40(Predicted)
- color
- Pale Yellow to Very Dark Yellow
- Merck
- 14,4088
- BRN
- 292829
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
- InChIKey
- XHEFDIBZLJXQHF-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC=C2C(=O)C=1O
- LogP
- 1.970 (est)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- LK9250000
- F
- 10
- TSCA
- Yes
- HS Code
- 29329990
Use
Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).
3 India supplier list of "Fisetin"
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- Product Name:Fisetin
- Company Type: Trader
- Country/Region: INDIA