Fludrocortisone acetate
Fludrocortisone acetate
- CAS:
- 514-36-3
- MF:
- C23H31FO6
- MW:
- 422.49
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Properties
- Melting point:
- 233-234°C
- alpha
- D23 +123° (c = 0.64 in chloroform)
- Boiling point:
- 575.1±50.0 °C(Predicted)
- Density
- 1.0953 (rough estimate)
- refractive index
- 1.5980 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, sparingly soluble in anhydrous ethanol.
- pka
- 12.06±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 54mg/L(25 ºC)
- InChIKey
- UUHYILPJUKGJDI-XYNXPQAZSA-N
- SMILES
- F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r|
Safety Information
- Symbol(GHS)
GHS07,GHS08
- Signal word
- Warning
- Hazard statements
- H302-H361
- Precautionary statements
- P280-P301+P312+P330
- Hazard Codes
- Xn
- Risk Statements
- 63
- Safety Statements
- 22-26-36
- WGK Germany
- 3
- RTECS
- TU5050000
- HS Code
- 2937220000
- Toxicity
- LD50 oral in rat: > 1gm/kg
Use
Fludrocortisone acetate,21-acetyloxy-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione, 9α-fluorohydrocortisone (Florinef Acetate), isused only for the treatment of Addison disease and for inhibitionof endogenous adrenocortical secretions. It has up to about 800 times the MC activity of hydrocortisone and about 11 times the GC activity. Its potent activity stimulated the synthesis and study of the many fluorinated steroids. Although its great salt-retaining activity limits its use to Addison disease, it has sufficient GC activity that in some cases of the disease, additional GCs need not be prescribed.
17 India supplier list of "Fludrocortisone acetate"
- Product Name:Fludrocortisone Acetate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:Fludrocortisone Acetate
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Fludrocortisoneacetate
- Products Intro:Brand:sigma aldrich | Product Number:F6127 | Purity:≥98%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Fludrocortisone Acetate
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Fludrocortisone acetate
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:FludrocortisoneAcetate
- Products Intro:Brand:pharmaffiliates | Product Number:PA0376510
- Company Type: Trader
- Country/Region: INDIA
- Product Name:Fludrocortisone Acetate
- Company Type: Reagent
- Country/Region: INDIA
- Product Name:Fludrocortisoneacetate
- Products Intro:Brand:ajchemicals | Product Number:JDH-68616 | Purity:95%
- Company Type: Trader
- Country/Region: INDIA
- Product Name:FLUDROCORTISONE ACETATE
- Company Type: Manufacturer
- Country/Region: INDIA
- Product Name:FludrocortisoneAcetate
- Products Intro:Brand:synzeal | Product Number:141801019
- Company Type: Trader
- Country/Region: INDIA