Fludrocortisone acetate
- CAS No.
- 514-36-3
- Chemical Name:
- Fludrocortisone acetate
- Synonyms
- 9α;U 4845;NSC 15186;cortineff;scherofluron;alfloroneacetate;Fluorocortisol acetate;FLUDROCORTISONE ACETATE;9-FLUOROCORTISOL ACETATE;9α-Fluorcortisol acetate
- CBNumber:
- CB5442481
- Molecular Formula:
- C23H31FO6
- Molecular Weight:
- 422.49
- MOL File:
- 514-36-3.mol
- Modify Date:
- 2024/7/2 8:55:11
| Melting point | 233-234°C |
|---|---|
| Boiling point | 575.1±50.0 °C(Predicted) |
| alpha | D23 +123° (c = 0.64 in chloroform) |
| Density | 1.0953 (rough estimate) |
| refractive index | 1.5980 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, sparingly soluble in anhydrous ethanol. |
| pka | 12.06±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 54mg/L(25 ºC) |
| InChIKey | UUHYILPJUKGJDI-XYNXPQAZSA-N |
| SMILES | F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r| |
| CAS DataBase Reference | 514-36-3(CAS DataBase Reference) |
| EPA Substance Registry System | Fluorocortisone acetate (514-36-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361 | |||||||||
| Precautionary statements | P280-P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63 | |||||||||
| Safety Statements | 22-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU5050000 | |||||||||
| HS Code | 2937220000 | |||||||||
| Toxicity | LD50 oral in rat: > 1gm/kg | |||||||||
| NFPA 704 |
|
Fludrocortisone acetate price More Price(2)
Fludrocortisone acetate Chemical Properties,Uses,Production
Description
Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 μg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 μg/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.
Chemical Properties
Crystalline Solid
Definition
ChEBI: An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid acti ns are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.
General Description
Fludrocortisone acetate,21-acetyloxy-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione, 9α-fluorohydrocortisone (Florinef Acetate), isused only for the treatment of Addison disease and for inhibitionof endogenous adrenocortical secretions. It has up to about 800 times the MC activity of hydrocortisone and about 11 times the GC activity. Its potent activity stimulated the synthesis and study of the many fluorinated steroids. Although its great salt-retaining activity limits its use to Addison disease, it has sufficient GC activity that in some cases of the disease, additional GCs need not be prescribed.
Clinical Use
Fludrocortisone acetate is mineralocorticoid. It is used as a replacement therapy in adrenal insufficiency. Fludrocortisone acetate tablets USP, 0.1 mg are indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome. ludrocortisone is a man-made form of a natural substance (glucocorticoid) made by the body. It is used along with other medications (such as hydrocortisone) to treat low glucocorticoid levels caused by disease of the adrenal gland (such as Addison's disease, adrenocortical insufficiency, salt-losing adrenogenital syndrome). Glucocorticoids are needed in many ways for the body to function well. They are important for salt and water balance and keeping blood pressure normal. They are also needed to break down carbohydrates in your diet.
Fludrocortisone acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Dharmanandan Export Pvt., Ltd. | 91-79-48402200 | Gujarat, India | 161 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
| Agio Pharmaceuticals Limited | 09049662833 | Pune, India | 2 | 58 | Inquiry |
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