GDC-0068
GDC-0068
- CAS:
- 1001264-89-6
- MF:
- C24H32ClN5O2
- MW:
- 458
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Company Type
Properties
- Melting point:
- >106°C (dec.)
- Boiling point:
- 669.4±55.0 °C(Predicted)
- Density
- 1.254
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Soluble in DMSO.
- pka
- 13.11±0.40(Predicted)
- form
- Solid
- color
- peachy
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Use
DC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2, and Akt3 with IC50 of 5 nM, 18 nM, and 8 nM, respectively.GDC-0068 is a highly selective AKT inhibitor targeting Akt1 , Akt2 and Akt3. Studies have shown its use in combination with vemurafenib (V118500), have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
2 India supplier list of "GDC-0068"
- Product Name:GDC-0068
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone
- Products Intro:Brand:pharmaffiliates | Product Number:PA090940000
- Company Type: Trader
- Country/Region: Haryana,INDIA