HET0016
HET0016
- CAS:
- 339068-25-6
- MF:
- C12H18N2O
- MW:
- 206.28
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Properties
- Melting point:
- 138-140°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Ethanol (Slightly)
- form
- Light pink solid.
- color
- White to Pale Yellow
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Use
20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.[Cayman Chemical]
0 India supplier list of "HET0016"
- Product Name:Het0016
- Products Intro:Purity: 95%+ | Package: 1g;5g;10g;25g;50g;100g; | CustNote: accept Custom Synthesis Services, support large packing
- Company Type: Trader
- Country/Region: CHINA