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HET0016

HET0016 Structure
CAS No.
339068-25-6
Chemical Name:
HET0016
Synonyms
HET0016;HET0016,HET-0016;N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine;N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE;N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide;N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide;N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE;Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-
CBNumber:
CB0149064
Molecular Formula:
C12H18N2O
Molecular Weight:
206.28
MOL File:
339068-25-6.mol
Modify Date:
2023/9/4 15:51:00
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HET0016 Properties

Melting point 138-140°C
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), Ethanol (Slightly)
form Light pink solid.
color White to Pale Yellow
CAS DataBase Reference 339068-25-6

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HET0016 Chemical Properties,Uses,Production

Description

20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.

Chemical Properties

Light Pink Solid

Uses

20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.[Cayman Chemical]

HET0016 Preparation Products And Raw materials

Raw materials

Preparation Products

HET0016 Suppliers

Global( 59)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19994 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3581 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
Beijing Stronger Science Co., Ltd. 0531-88924771 15614660963 China 10624 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
Hebei Miaoyin Technology Co.,Ltd 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Beijing Stronger Science Co., Ltd. 58
Cayman Chemical Company 81

HET0016 Spectrum

HET0016(339068-25-6)1HNMR

339068-25-6(HET0016)Related Search:

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE RESORUFIN ETHYL ETHER 4-Butyl-2-methylaniline N-(4-BUTYL-2-METHYLPHENYL)-N'-[(4-CHLORO-3-NITROBENZOYL)OXY]IMINOFORMAMIDE HET0016
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HET0016 N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy- HET0016,HET-0016 339068-25-6 Aromatics