Mecillinam manufacturers and suppliers in india

Mecillinam

Properties

Melting point:: 156°C

Boiling point:: 551℃

alpha: D20 +285° (c = 1 in 0.1N HCl)

Density: 1.44±0.1 g/cm3(Predicted)

Flash point:: >110°(230°F)

storage temp.: Sealed in dry,2-8°C

solubility: Methanol (Slightly), Water (Slightly)

pka: pKa 3.40 (Uncertain)

form: Solid

color: White to Off-White

Water Solubility: Soluble in water at approximately 1mg/ml

Safety Information

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 2

RTECS: XI0185000

Use

Oral absorption (pivmecillinam): c. 75% Cmax 200 mg intravenous infusion: 12 mg/L end infusion 200 mg intramuscular: c. 6 mg/L after 45 min 400 mg oral (pivmecillinam): 25 mg/L after c. 1 h Plasma half-life: 50 min Volume of distribution: 0.20.4 L/kg Plasma protein binding: 510% Absorption Oral absorption is very poor, with conventional doses producing plasma levels of 1 mg/L and recovery of only about 5% in the urine. A 400 mg dose of the pivaloyl ester is equivalent to 273 mg mecillinam. It is relatively well absorbed and rapidly liberates the parent compound. Metabolism and excretion The amidino side chain undergoes spontaneous aqueous hydrolysis to the N-formyl derivative, which retains some antibacterial activity. Hydrolysis of the -lactam ring also occurs. Approximately 60% is excreted unchanged in the urine in the first 6 h, achieving concentrations exceeding 1 g/L. The concentration in bile can reach 40 or 50 mg/L in patients with normally functioning gallbladders treated with 800 mg intramuscularly.