Moxonidine manufacturers and suppliers in india

Moxonidine

Properties

Melting point:: 217-219° (dec)

Boiling point:: 364.7±52.0 °C(Predicted)

Density: 1.52±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.

pka: 7.11±0.10(Predicted)

form: Solid

color: White to Almost white

Water Solubility: 800.3mg/L(temperature not stated)

Merck: 14,6293

InChIKey: WPNJAUFVNXKLIM-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS09,GHS06

Signal word: Danger

Hazard statements: H411-H301

Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501

RIDADR: UN 2811 6.1/PG III

WGK Germany: 3

RTECS: UV6260290

HS Code: 2933.99.5300

HazardClass: 6.1

PackingGroup: III

Use

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata. Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure. It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the 2-receptor. In contrast, clonidine binds to both receptors with equal affinity. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.