Neomycin sulfate manufacturers and suppliers in india

Properties

Melting point:: >187°C (dec.)

alpha: D20 +54° (c = 2 in H2O)

bulk density: 640kg/m3

refractive index: 56 ° (C=10, H2O)

Flash point:: 56℃

storage temp.: 2-8°C

solubility: H₂O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.

form: powder

color: white to slightly yellow

PH: 5.0-7.5 (50g/l, H2O, 20℃)

biological source: Streptomyces sp.

Water Solubility: Soluble in water

Merck: 14,6454

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: OIXVKQDWLFHVGR-VTSVPHRWSA-N

LogP: -3.655 (est)

CAS DataBase Reference: 1405-10-3(CAS DataBase Reference)

EPA Substance Registry System: Neomycin sulfate (1405-10-3)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H317-H334

Precautionary statements: P261-P280-P342+P311

Hazard Codes: Xn,Xi

Risk Statements: 42/43-22

Safety Statements: 23-36/37-45-22-36-24/25

WGK Germany: 3

RTECS: QP4375000

F: 8

TSCA: Yes

HS Code: 29419000

Toxicity: LD50 oral in mouse: > 8gm

Use

Neomycin sulfate, a broad-spectrum antibiotic, was first isolated in 1949 and has subsequently been included in topical, oral and parenteral preparations. Its value in the treatment of diarrhoea is widely questioned although it is still contained in a number of widely available antidiarrhoeal preparations. In some countries the officially approved indications for oral preparations are restricted to the preparation of the bowel prior to surgery and the management of hepatic coma.NEOMYCIN SULFATE is white or yellowish-white powder, hygroscopic. NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. Neomycin has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures. NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.