Nizatidine
Nizatidine
- CAS:
- 76963-41-2
- MF:
- C12H21N5O2S2
- MW:
- 331.46
Suppliers by country/region
Company Type
Properties
- Melting point:
- 130-1320C
- Boiling point:
- 478.2±45.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Sparingly soluble in water, soluble in methanol.
- form
- Solid
- pka
- 2.1, 6.8(at 25℃)
- color
- Off-White to Pale Yellow
- Water Solubility
- 21.4g/L(temperature not stated)
- Merck
- 14,6660
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P501
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 36
- WGK Germany
- 3
- RTECS
- KM6565000
- HS Code
- 29349990
- Toxicity
- LD50 in mice, rats (mg/kg): 265, >300 i.v.; 1685, 1680 orally (Pioch)
Use
Nizatidine, N-[2-[[[2-(dimethylamino)methyl]-4-thiazolyl]methyl]thio]-ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Axid), is an off-white to buff crystallinesolid that is soluble in water, alcohol, and chloroform. It isa thaizole derivative of raniditine and has pKas of 2.1 (side chain) and 6.8 (dimethylamino). Nizatidine’s mechanism ofaction is similar to other H2-antagonists, as is its receptor selectivity.It is more potent than cimetidine.Nizatidine has excellent oral bioavailability (>90%).The effects of antacids or food on its bioavailability arenot clinically significant. The elimination half-life is 1 to2 hours. It is excreted primarily in the urine (90%) andmostly as unchanged drug (60%). Metabolites include nizatidinesulfoxide (6%), N-desmethylnizatidine (7%), andnizatidine N-oxide (dimethylaminomethyl function).Nizatidine has no demonstrable antiandrogenic action, effectson other hormones, or inhibitory effects on cytochromeisozymes involved in the metabolism of other drugs.
32 India supplier list of "Nizatidine"
- Product Name:Nizatidine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Nizatidine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Nizatidine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Nizatidine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Nizatidine
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Nizatidine
- Products Intro:Brand:synzeal | Product Number:185450526
- Company Type: Trader
- Country/Region: Gujarat,INDIA