Nizatidine
- CAS No.
- 76963-41-2
- Chemical Name:
- Nizatidine
- Synonyms
- axid;nizax;ze-101;Nizaxi;ZL-101;Acinon;nizaxid;gastrax;zanizal;Tizanon
- CBNumber:
- CB9739336
- Molecular Formula:
- C12H21N5O2S2
- Molecular Weight:
- 331.46
- MOL File:
- 76963-41-2.mol
- Modify Date:
- 2024/7/2 8:55:42
| Melting point | 130-1320C |
|---|---|
| Boiling point | 478.2±45.0 °C(Predicted) |
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Sparingly soluble in water, soluble in methanol. |
| form | Solid |
| pka | 2.1, 6.8(at 25℃) |
| color | Off-White to Pale Yellow |
| Water Solubility | 21.4g/L(temperature not stated) |
| Merck | 14,6660 |
| CAS DataBase Reference | 76963-41-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KM6565000 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 265, >300 i.v.; 1685, 1680 orally (Pioch) | |||||||||
| NFPA 704 |
|
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Nizatidine Chemical Properties,Uses,Production
Description
Nizatidine is the fifth H2-antagonist introduced to the world market as an antiulcer agent. It is reported to be effective in the treatment of both duodenal and gastric ulcers or the prevention of their recurrences. Given once-daily, nizatidine’s bioavailability is not diminished by the concurrent administration of an antacid.
Chemical Properties
White Crystalline Powder
Uses
Nizatidine is used for treating stomach and duodenum ulcers and other conditions accompanied by elevated acidity of the gastrointestinal tract.
Indications
Nizatidine is the newest H2-receptor antagonist. Similar to ranitidine, it has a relative potency twice that of cimetidine.About 90% of an oral dose is absorbed, with a peak plasma concentration occurring after 0.5 to 3 hours; inhibition of gastric secretion is present for up to 10 hours.The elimination half-life is 1 to 2 hours, and more than 90% of an oral dose is excreted in the urine.
Definition
ChEBI: A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.
General Description
Nizatidine, N-[2-[[[2-(dimethylamino)methyl]-4-thiazolyl]methyl]thio]-ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Axid), is an off-white to buff crystallinesolid that is soluble in water, alcohol, and chloroform. It isa thaizole derivative of raniditine and has pKas of 2.1 (side chain) and 6.8 (dimethylamino). Nizatidine’s mechanism ofaction is similar to other H2-antagonists, as is its receptor selectivity.It is more potent than cimetidine.
Nizatidine has excellent oral bioavailability (＞90%).The effects of antacids or food on its bioavailability arenot clinically significant. The elimination half-life is 1 to2 hours. It is excreted primarily in the urine (90%) andmostly as unchanged drug (60%). Metabolites include nizatidinesulfoxide (6%), N-desmethylnizatidine (7%), andnizatidine N-oxide (dimethylaminomethyl function).Nizatidine has no demonstrable antiandrogenic action, effectson other hormones, or inhibitory effects on cytochromeisozymes involved in the metabolism of other drugs.
Nizatidine Preparation Products And Raw materials
Raw materials
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| SOLARA ACTIVE PHARMA SCIENCES LIMITED | +91 80 46632100 | New Delhi, India | 16 | 58 | Inquiry |
| DR. REDDY'S LABORATORIES LIMITED | +91.40.4900 2900 | New Delhi, India | 59 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
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