O-Desmethylvenlafaxine
O-Desmethylvenlafaxine
- CAS:
- 93413-62-8
- MF:
- C16H25NO2
- MW:
- 263.38
Suppliers by country/region
Company Type
Properties
- Melting point:
- 208-213°C
- Boiling point:
- 403.8±25.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
- form
- Solid
- pka
- 10.04±0.26(Predicted)
- color
- White to off-white
- InChIKey
- KYYIDSXMWOZKMP-UHFFFAOYSA-N
- LogP
- 0.33 at 25℃ and pH6
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H319
- Precautionary statements
- P305+P351+P338
- Hazard Codes
- F,T,Xi
- Risk Statements
- 11-23/24/25-39/23/24/25-36
- Safety Statements
- 7-16-36/37-45-26
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- GV8872620
- HS Code
- 29225090
Use
Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
41 India supplier list of "O-Desmethylvenlafaxine"
- Product Name:O-Desmethylvenlafaxine
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:O-Desmethyl Venlafaxine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Ahmedabad,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Bangalore,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Mumbai,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Venlafaxine O-Desmethyl
- Products Intro:Purity: 98% | Package: 25mg, 50mg,100mg,200mg
- Company Type: Manufacturer
- Country/Region: Mumbai,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Desvenlafaxine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA