O-Desmethylvenlafaxine
- CAS No.
- 93413-62-8
- Chemical Name:
- O-Desmethylvenlafaxine
- Synonyms
- DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36;Venlafaxine O-Desmethyl
- CBNumber:
- CB8496834
- Molecular Formula:
- C16H25NO2
- Molecular Weight:
- 263.38
- MOL File:
- 93413-62-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:37
| Melting point | 208-213°C |
|---|---|
| Boiling point | 403.8±25.0 °C(Predicted) |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH |
| form | Solid |
| pka | 10.04±0.26(Predicted) |
| color | White to off-white |
| InChIKey | KYYIDSXMWOZKMP-UHFFFAOYSA-N |
| LogP | 0.33 at 25℃ and pH6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | F,T,Xi | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25-36 | |||||||||
| Safety Statements | 7-16-36/37-45-26 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GV8872620 | |||||||||
| HS Code | 29225090 | |||||||||
| NFPA 704 |
|
O-Desmethylvenlafaxine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | V-045 | O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? | 93413-62-8 | 1ML | ₹39022.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | V-007 | O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 93413-62-8 | 1ML | ₹9615.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 93867 | O-Desmethylvenlafaxine analytical standard | 93413-62-8 | 50MG | ₹11171.4 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D5598 | O-Desmethylvenlafaxine | 93413-62-8 | 1G | ₹5100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D5598 | O-Desmethylvenlafaxine | 93413-62-8 | 5G | ₹10100 | 2022-05-26 | Buy |
O-Desmethylvenlafaxine Chemical Properties,Uses,Production
Description
Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
Chemical Properties
White Solid
Uses
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Definition
ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
General Description
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
O-Desmethylvenlafaxine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
| GLP Pharma Standards | +91 9866074638 | Hyderabad, India | 1644 | 58 | Inquiry |
| Dodhia Group | +91-9619867345 +91-9619867345 | Mumbai, India | 129 | 58 | Inquiry |
| Alembic Pharmaceuticals Limited | +91-2652280880 +91-2652280550 | Gujarat, India | 115 | 58 | Inquiry |
| Macleods Pharmaceuticals Limited | +91-2266762800 +91-2266762800 | Maharashtra, India | 116 | 58 | Inquiry |
| SNJ Labs Pvt Ltd | +91-9033216399 +91-9824296655 | Gujarat, India | 17 | 58 | Inquiry |
| Besil Chem LLP | +91-7760252666 +91-9880731835 | Bangalore, India | 163 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Cadila Pharmaceuticals Ltd | 58 |
| SynThink RESEARCH CHEMICALS | 58 |
| GLP Pharma Standards | 58 |
| Dodhia Group | 58 |
| Alembic Pharmaceuticals Limited | 58 |
| Macleods Pharmaceuticals Limited | 58 |
| SNJ Labs Pvt Ltd | 58 |
| Besil Chem LLP | 58 |
| Ralington Pharma | 58 |
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