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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor modulators >O-Desmethylvenlafaxine

O-Desmethylvenlafaxine

O-Desmethylvenlafaxine Structure
  • ₹5100 - ₹39022.2
  • Product name: O-Desmethylvenlafaxine
  • CAS: 93413-62-8
  • MF: C16H25NO2
  • MW: 263.38
  • EINECS:700-516-2
  • MDL Number:MFCD00871934
  • Synonyms:O-DESMETHYL VENLAFAXINE-D10;DL-O-Desmethylvenlafaxin;4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;O-Desmethylvenlafaxine;Desvenlafaxine(O-Desnethylvenfaxine);1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol;4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol;Desmethylvenlafaxine
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 50MG
  • 1G
  • 1ML
  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product numberV-045
  • Product descriptionO-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹39022.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number93867
  • Product descriptionO-Desmethylvenlafaxine analytical standard
  • Packaging50MG
  • Price₹11171.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV-007
  • Product descriptionO-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹9615.9
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5598
  • Product descriptionO-Desmethylvenlafaxine
  • Packaging5G
  • Price₹10100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5598
  • Product descriptionO-Desmethylvenlafaxine
  • Packaging1G
  • Price₹5100
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) V-045 O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? 1ML ₹39022.2 2022-06-14 Buy
Sigma-Aldrich(India) 93867 O-Desmethylvenlafaxine analytical standard 50MG ₹11171.4 2022-06-14 Buy
Sigma-Aldrich(India) V-007 O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹9615.9 2022-06-14 Buy
TCI Chemicals (India) D5598 O-Desmethylvenlafaxine 5G ₹10100 2022-05-26 Buy
TCI Chemicals (India) D5598 O-Desmethylvenlafaxine 1G ₹5100 2022-05-26 Buy

Properties

Melting point :208-213°C
Boiling point :403.8±25.0 °C(Predicted)
Density :1.115±0.06 g/cm3(Predicted)
Flash point :9℃
storage temp. :2-8°C
solubility :insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
form :Solid
pka :10.04±0.26(Predicted)
color :White to off-white
InChIKey :KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP :0.33 at 25℃ and pH6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

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GLR Innovations Cadila Pharmaceuticals Ltd SynThink RESEARCH CHEMICALS Dodhia Group Alembic Pharmaceuticals Limited Macleods Pharmaceuticals Limited SNJ Labs Pvt Ltd Besil Chem LLP Ralington Pharma Sai Teja Drugs and Intermediates Pvt Ltd