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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor modulators >O-Desmethylvenlafaxine

O-Desmethylvenlafaxine

O-Desmethylvenlafaxine Structure
  • ₹5100 - ₹39022.2
  • Product name: O-Desmethylvenlafaxine
  • CAS: 93413-62-8
  • MF: C16H25NO2
  • MW: 263.38
  • EINECS:700-516-2
  • MDL Number:MFCD00871934
  • Synonyms:O-DESMETHYL VENLAFAXINE-D10;DL-O-Desmethylvenlafaxin;4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;O-Desmethylvenlafaxine;Desvenlafaxine(O-Desnethylvenfaxine);1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol;4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol;Desmethylvenlafaxine
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 1ML
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberD5598
  • Product descriptionO-Desmethylvenlafaxine
  • Packaging1G
  • Price₹5100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5598
  • Product descriptionO-Desmethylvenlafaxine
  • Packaging5G
  • Price₹10100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV-007
  • Product descriptionO-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹9615.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number93867
  • Product descriptionO-Desmethylvenlafaxine analytical standard
  • Packaging50MG
  • Price₹11171.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV-045
  • Product descriptionO-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹39022.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D5598 O-Desmethylvenlafaxine 1G ₹5100 2022-05-26 Buy
TCI Chemicals (India) D5598 O-Desmethylvenlafaxine 5G ₹10100 2022-05-26 Buy
Sigma-Aldrich(India) V-007 O-Desmethylvenlafaxine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹9615.9 2022-06-14 Buy
Sigma-Aldrich(India) 93867 O-Desmethylvenlafaxine analytical standard 50MG ₹11171.4 2022-06-14 Buy
Sigma-Aldrich(India) V-045 O-Desmethylvenlafaxine solution 1.0?mg/mL in methanol, certified reference material, Cerilliant? 1ML ₹39022.2 2022-06-14 Buy

Properties

Melting point :208-213°C
Boiling point :403.8±25.0 °C(Predicted)
Density :1.115±0.06 g/cm3(Predicted)
Flash point :9℃
storage temp. :2-8°C
solubility :insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
form :Solid
pka :10.04±0.26(Predicted)
color :White to off-white
InChIKey :KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP :0.33 at 25℃ and pH6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

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GLR Innovations Cadila Pharmaceuticals Ltd SynThink RESEARCH CHEMICALS GLP Pharma Standards Dodhia Group Alembic Pharmaceuticals Limited Macleods Pharmaceuticals Limited SNJ Labs Pvt Ltd Besil Chem LLP Ralington Pharma