PF-03814735
PF-03814735
- CAS:
- 942487-16-3
- MF:
- C23H25F3N6O2
- MW:
- 474.48
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Company Type
Properties
- Melting point:
- 181-183°C
- Density
- 1.443
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 15.02±0.46(Predicted)
- color
- white to beige
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
- WGK Germany
- 3
Use
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.[Cayman Chemical]
0 India supplier list of "PF-03814735"
- Product Name:PF-03814735
- Products Intro:Brand:sigma aldrich | Product Number:PZ0218 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
-
1g$1
- Product Name:PF-03814735
- Products Intro:Purity: 0.99， AD68|Package: 1g;1USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Methyl 3-amino-2-fluorobenzoate
- Product Name:PF-03814735
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:PF-03814735 PF03814735
- Products Intro:Purity: 99% | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
-
2mg$65.005mg$108.001mL*10mM(inDMSO)$124.0010mg$189.0025mg$396.0050mg$657.00
- Product Name:PF-03814735
- Products Intro:Brand:TargetMol | Product Number:T6936 | Purity:98%
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:PF-03814735
- Products Intro:Purity: 99% | Package: 1KG;25kg;200kg;1000kg Jessica | CustNote: g-kg-tons,free sample is available.Bottle/drum/IBC.Advantage products,new batches,regular stock, ready for shipment.
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Chemical raw materials,Organic raw materials,Petrochemicals,Chemical reagents,Intermediates
- Product Name:N-(2-((1S,4R)-6-((4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide
- Products Intro:Purity: 95%+ | Package: 1g;5g;10g;25g;50g;100g; | CustNote: accept Custom Synthesis Services, support large packing
- Company Type: Trader
- Country/Region: CHINA
- Main Products: cof,mof
- Product Name:PF-03814735
- Products Intro:Purity: 98% | Package: $24.9/1mg;$102.9/5mg;$165.9/10mg;$711.9/50mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:PF-03814735
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A916762
- Company Type: Reagent
- Country/Region: CHINA
-
5 mg$101.0025 mg$399.00
- Product Name:PF-03814735
- Products Intro:Brand：Sigma-Aldrich | Product Number：PZ0218 | Purity：≥98%(HPLC)
- Company Type: Trader
- Country/Region: UNITED STATES