Pleuromulin
Pleuromulin
- CAS:
- 125-65-5
- MF:
- C22H34O5
- MW:
- 378.5
Suppliers by country/region
Company Type
Properties
- Melting point:
- 170-1710C
- alpha
- D24 +20° (c = 3 in abs ethanol)
- Boiling point:
- 482.8±45.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO: >10mg/mL (warmed)
- form
- powder
- pka
- 12.91±0.10(Predicted)
- color
- white to beige
- optical activity
- [α]/D +30 to +40° (c=1; CH2Cl2)
- InChIKey
- YSBXUHAJXRCCET-BKUNHTPHSA-N
Safety Information
- Symbol(GHS)
GHS07,GHS09
- Signal word
- Warning
- Hazard statements
- H302-H410
- Precautionary statements
- P264-P270-P273-P301+P312-P391-P501
- WGK Germany
- 3
- RTECS
- MC5408000
- Toxicity
- LD50 in mice: >60 mg/kg (Kavanagh, 1952)
Use
Pleuromulin is Crystalline Solid Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin. Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.
0 India supplier list of "Pleuromulin"
- Product Name:Pleuromutilin
- Products Intro:Brand:sigma aldrich | Product Number:SML0285 | Purity:≥95%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Pleuromutilin
- Products Intro:Brand:pharmaffiliates | Product Number:PA2033070
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:TiamulinEPImpurityG
- Products Intro:Brand:synzeal | Product Number:174213223
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:antibioticbc757
- Products Intro:Purity: 99% | Package: 25KG
- Company Type: Service provider
- Country/Region: CHINA
- Main Products: carbomer,lead acetate,phenylacetamide,Xylazine,Xylazine hcl
$0.00/ 25KG
- Product Name:Pleuromulin
- Products Intro:Purity: 0.99|Package: 1kg;30.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Povidone Iodine,Polyquaternium-7,1,2,3-Triacetyl-5-deoxy-D-ribose,Diethyl L-glutamate hydrochloride,Hydroquinone
$30.00/ 1kg
- Product Name:Pleuromulin
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$1.00/ 1KG
- Product Name:Pleuromulin
- Products Intro:Purity: 99% | Package: 1KG;10USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: DHA,4'-Methylpropiophenone,Procaine hcl,tetramisole hcl,lidocaine
$10.00/ 1KG