Probucol manufacturers and suppliers in india

Probucol

Properties

Melting point:: 126-128°C

Boiling point:: 571.58°C (rough estimate)

Density: 1.0008 (rough estimate)

refractive index: 1.5341 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)

pka: 10.27±0.70(Predicted)

form: Solid

color: White to Off-White

Merck: 14,7755

InChIKey: FYPMFJGVHOHGLL-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P280-P305+P351+P338

WGK Germany: 2

RTECS: AL3705000

HS Code: 2930902000

Use

Probucol, 4,4＇ -[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol], DH-581(Lorelco), is a chemical agent that was developed for the plasticsand rubber industry in the 1960s. The probucol moleculehas two tertiary butylphenol groups linked by a dithiopropylidenebridge, giving it a high lipophilic character with strongantioxidant properties. In humans, it causes reduction of bothliver and serum cholesterol levels, but it does not alter plasmatriglycerides. It reduces LDL and (to a lesser extent) HDLlevels by a unique mechanism that is still not clearly delineated.The reduction of HDL may be caused by the ability ofprobucol to inhibit the synthesis of apoprotein A-1, a majorprotein component of HDL. It is effective at reducing levelsof LDL and is used in hyperlipoproteinemias characterized byelevated LDL levels.