PUROMYCIN
PUROMYCIN
- CAS:
- 53-79-2
- MF:
- C22H29N7O5
- MW:
- 471.51
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Properties
- Melting point:
- 175.5-177°
- alpha
- D25 -11° (ethanol)
- Boiling point:
- 572.65°C (rough estimate)
- Density
- 1.3119 (rough estimate)
- refractive index
- 1.7010 (estimate)
- RTECS
- AU7350000
- pka
- 6.8, 7.2(at 25℃)
- form
- Liquid
- Water Solubility
- Soluble in water (50 mg/ml at 20°C).
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312a-P330-P501a
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 in mice (mg/kg): 350 i.v.; 525 i.p.; 675 orally (Porter, 1952)
Use
Puromycin is a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypanosomal agent with antibiotic activity. Puromycin is non-selective, inhibiting RNA by blocking ribosomal translation. Puromycin is used in cell biology to select mammalian cell lines that have been transformed by vectors that express puromycin-N-acetyl-transferase.
1 India supplier list of "PUROMYCIN"