Ristocetin
Ristocetin
- CAS:
- 11021-66-2
- MF:
- C95H110N8O44
- MW:
- 2067.92
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Properties
- alpha
- D -120 to -133° (water)
- Density
- 1.76±0.1 g/cm3(Predicted)
- pka
- 8.55±0.70(Predicted)
Safety Information
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- mouse,LD50,intravenous,1350mg/kg (1350mg/kg),SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE,"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 568, 1967.
Use
Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.
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