Scopolamine
Scopolamine
- CAS:
- 51-34-3
- MF:
- C17H21NO4
- MW:
- 303.35
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Company Type
Properties
- Melting point:
- 59 ºC
- alpha
- D20 -28° (c = 2.7)
- Boiling point:
- 444.28°C (rough estimate)
- Density
- 1.31
- refractive index
- 1.5022 (estimate)
- Flash point:
- 232.2℃
- storage temp.
- -20°C
- solubility
- Soluble in water, freely soluble in ethanol (96 per cent).
- pka
- 7.55-7.81(at 25℃)
- form
- <55°C solid,>55°C liquid
- color
- White to off-white
- Water Solubility
- 95g/L(15 ºC)
- LogP
- 0.980
Safety Information
- Symbol(GHS)
GHS05,GHS06
- Signal word
- Danger
- Hazard statements
- H300+H310+H330-H317-H318
- Precautionary statements
- P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338
- Hazard Codes
- T+
- Risk Statements
- 26/27/28
- Safety Statements
- 25-45
- RIDADR
- UN 1544PSN2 6.1 / PGII
- HS Code
- 29399990
- Toxicity
- A belladonna plant alkaloid that exerts its pharmacodynamic effects by blocking muscarinic acetylcholine receptor sites. The s.c. LD50 of scopolamine hydrobromide in mice is 3.8 g/kg. Scopolamine crosses the blood brain barrier, and its antimuscarinic effects include, in therapeutic doses, drowsiness, euphoria, amnesia, fatigue, loss of REM sleep and, at higher doses, restlessness or even delirium. Scopolamine can be used to treat motion sickness and parkinsonian tremor. The effects of scopolamine may be greater in the CNS than atropine, and it may be a better antidote for organophosphate intoxication.
Use
The commercially available transdermal system of scopolaminecomprises an outer layer of polymer film and a drug reservoircontaining scopolamine, polyisobutylene, and mineral oil, which is interfaced with a microporous membrane tocontrol diffusion of the drug. In this dosage form, scopolamineis effective in preventing motion sickness. The actionis believed to be on the cortex or the vestibular apparatus.Whereas atropine stimulates the CNS, causing restlessnessand talkativeness, scopolamine usually acts as a CNSdepressant.
6 India supplier list of "Scopolamine"
- Product Name:Scopolamine
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:HYOSCINE EP IMPURITY A
- Products Intro:Purity: 99.90 | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Hyderabad,INDIA
- Product Name:Scopolamine
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Punjab,INDIA
- Product Name:Hyoscine Ph . Eur
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:ANTI-PHLPP1(N-TERMINAL)antibodyproducedinrabbit
- Products Intro:Brand:sigma aldrich | Product Number:SAB1305348 | Purity:purifiedimmunoglobulin,bufferedaqueoussolution
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Scopolamine 97%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.129777
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Scopolamine
- Products Intro:Brand:clearsynth | Product Number:CS-T-61247
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Hyoscine
- Products Intro:Brand:pharmaffiliates | Product Number:PA010850060
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Scopolamine
- Products Intro:Brand:ajchemicals | Product Number:JDH-55227 | Purity:95%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Scopolamine
- Company Type: Reagent
- Country/Region: Haryana,INDIA