Tamoxifen
Tamoxifen
- CAS:
- 10540-29-1
- MF:
- C26H29NO
- MW:
- 371.51
Suppliers by country/region
Company Type
Properties
- Melting point:
- 97-98 °C(lit.)
- Boiling point:
- 501.18°C (rough estimate)
- Density
- 1.0630 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- H2O: insoluble <0.1% at 20°C
- pka
- pKa 8.71(H2O t = 25 I = 0.025) (Uncertain)
- form
- Solid
- color
- Crystals from pet ether
- Water Solubility
- Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.
- Merck
- 13,9137
- Stability:
- Light Sensitive
- InChIKey
- NKANXQFJJICGDU-QPLCGJKRSA-N
- LogP
- 6.3 at 20℃
- CAS DataBase Reference
- 10540-29-1(CAS DataBase Reference)
- IARC
- 1 (Vol. 66, 100A) 2012
- EPA Substance Registry System
- Tamoxifen (10540-29-1)
Safety Information
- Symbol(GHS)
GHS08,GHS09
- Signal word
- Danger
- Hazard statements
- H350-H360-H410
- Precautionary statements
- P201-P273-P308+P313
- Hazard Codes
- T,Xi
- Risk Statements
- 45-60-61-64-36/37/38
- Safety Statements
- 53-45-36-26
- WGK Germany
- 3
- RTECS
- KR5919600
- HS Code
- 29221990
- Hazardous Substances Data
- 10540-29-1(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 4100 mg/kg DRFUD4 9,186,84
Use
Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response mo difiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
2 India supplier list of "Tamoxifen"
- Product Name:Tamoxifen
- Products Intro:Brand:sigma aldrich | Product Number:T5648 | Purity:≥99%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Tamoxifen 95.00%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.076713
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Tamoxifen
- Products Intro:Brand:clearsynth | Product Number:CS-T-43118
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:Tamoxifen
- Products Intro:Brand:ajchemicals | Product Number:JDH-66043 | Purity:98%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Tamoxifen Base
- Company Type: Reagent
- Country/Region: Uttar Pradesh,INDIA
- Product Name:Tamoxifen
- Products Intro:Brand:pharmaffiliates | Product Number:PA2003000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:tamoxifen
- Products Intro:Purity: 0.99 | Package: 100g;10g;1g;100mg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Tamoxifen
- Products Intro:Purity: 99% | Package: 1g;1USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pmk,bmk,hgh191aa,sarms,HCG
$19.00/ 1KG
- Product Name:Tamoxifen
- Products Intro:Purity: 99.%|Package: 1KG;19.00;USD
- Company Type: Trader
- Country/Region: CHINA
- Main Products: acetic acid,Ethyl oleate,Hypophosphorous acid,tetramisole,OPP