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TEMAZEPAM
TEMAZEPAM
- CAS:
- 846-50-4
- MF:
- C16H13ClN2O2
- MW:
- 300.74
Properties
- Melting point:
- 119-121°C
- Boiling point:
- 211°C (rough estimate)
- Density
- 1.2682 (rough estimate)
- refractive index
- 1.5200 (estimate)
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
- pka
- pKa 1.6 (Uncertain)
- BCS Class
- 2
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-39/23/24/25-23/24/25-11
- Safety Statements
- 16-36/37-45-7
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- DF1225000
- HS Code
- 2933910000
- Toxicity
- LD50 oral in rat: 2gm/kg
Use
Temazepam, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl -2H-1,4-benzodiazepine-2-one(Restoril), also occurs as a minor metabolite of diazepam.It can be visualized as N-methyl oxazepam, and indeed, asmall amount of N-demethylation occurs slowly. However,metabolism proceeds mainly through glucuronidationof the 3-hydroxyl group, thus, it is intermediate acting andmarketed as a hypnotic said to have little or no residualeffect.
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