thenalidine

CAS:: 86-12-4

MF:: C17H22N2S

MW:: 286.43

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Properties

Melting point:: 95-97°

Boiling point:: bp0.02 158-160°

Density: 1.140±0.06 g/cm3(Predicted)

pka: pKa 3.36±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.39±0.07(H2O t undefined I = 0.30 (NaCl)) (Uncertain)

Safety Information

Use

Thenalidine, a piperidine antihistamine, was introduced in 1953 for the management of dermatologic and allergic conditions. By 1958 its use had been associated with cases of severe neutropenia, two of them fatal, which led to its withdrawal in the United States of America and subsequently in the United Kingdom. Over the next fifteen years, continued reports of its association with cases of neutropenia resulted in further withdrawals in many countries. It is apparently still available, however, in some combination products.