Thiamphenicol manufacturers and suppliers in india

Thiamphenicol

Properties

Melting point:: 163-166 °C

alpha: D25 +12.9° (ethanol)

Density: 1.3281 (rough estimate)

refractive index: 1.6000 (estimate)

storage temp.: Sealed in dry,Room Temperature

solubility: ethanol: 50 mg/mL, clear, colorless

Boiling point:: 695.9±55.0 °C(Predicted)

pka: 11.05±0.46(Predicted)

form: powder

color: white to off-white

Water Solubility: Soluble in acetonitrile or DMF. Slightly soluble in water

Merck: 14,9301

BRN: 2819542

InChIKey: OTVAEFIXJLOWRX-NXEZZACHSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Safety Statements: 22-24/25

WGK Germany: 2

RTECS: AB6680000

HS Code: 29414000

Toxicity: human,TDLo,unreported,214mg/kg/10D (214mg/kg),BEHAVIORAL: SLEEPGASTROINTESTINAL: NAUSEA OR VOMITINGSKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE",Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 944, 1974.

Use

Thiamphenicol is a semi-synthetic chloramphenicol prepared by total synthesis from thiophenol in which the nitro moiety of chloramphenicol is replaced by a methylsulphone, first synthesised at Sterling Winthrop in 1952. Thiamphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Thiamphenicol acts by binding to the 23S sub-unit of the 50S ribosome inhibiting protein synthesis. Thiamphenicol has been extensively studied with over 800 literature citations.