Tolvaptan
Tolvaptan
- CAS:
- 150683-30-0
- MF:
- C26H25ClN2O3
- MW:
- 448.94
Suppliers by country/region
Company Type
Properties
- Melting point:
- 219-222°C
- Boiling point:
- 594.4±50.0 °C(Predicted)
- Density
- 1.311±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥15mg/mL
- form
- powder
- pka
- 13.00±0.70(Predicted)
- color
- white to tan
- InChIKey
- GYHCTFXIZSNGJT-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Warning
- Hazard statements
- H362-H361
- Precautionary statements
- P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
- WGK Germany
- 3
Use
Tolvaptan(SAMSCA) should be initiated and re-initiated in patients only in a hospital where serum sodium can be monitored closely. Too rapid correction of hyponatremia (e.g., 12 mEq/L/24 hours) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and death. In susceptible patients, including those with severe malnutrition, alcoholism or advanced liver disease, slower rates of correction may be advisable. Tolvaptan(SAMSCA) is contraindicated in the following conditions: Urgent need to raise serum sodium acutely Inability of the patient to sense or appropriately respond to thirst Hypovolemic hyponatremia Concomitant use of strong CYP 3A inhibitors Anuric patients Hypersensitivity (e.g. anaphylactic shock, rash generalized) to tolvaptan or its components
35 India supplier list of "Tolvaptan"
- Product Name:Tolvaptan
- Products Intro:Purity: 97% | Package: 1 MG,10MGg, 100MGg and1000MGg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:Tolvaptan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Tolvaptan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Tolvaptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Tolvaptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Gujarat,INDIA
- Product Name:Tolvaptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Maharashtra,INDIA
- Product Name:Tolvaptan
- Products Intro:Brand:sigma aldrich | Product Number:T7455 | Purity:≥98%(HPLC),powder
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Tolvaptan
- Company Type: Reagent
- Country/Region: Gujarat,INDIA