ABT 263
ABT 263
- CAS:
- 923564-51-6
- MF:
- C47H55ClF3N5O6S3
- MW:
- 974.61
Suppliers by country/region
Company Type
Properties
- Melting point:
- 114-116°C
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- solid
- pka
- 4.60±0.10(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
- HS Code
- 29339900
Use
ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 M. All four cell lines with EC50 values of 400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.
2 India supplier list of "ABT 263"
- Product Name:ABT-263 >95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.089568
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:ABT 263
- Company Type: Reagent
- Country/Region: Haryana,INDIA
- Product Name:ABT-263
- Products Intro:Brand:ajchemicals | Product Number:JDH-26039 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Navitoclax
- Products Intro:Brand:pharmaffiliates | Product Number:PA1482000
- Company Type: Trader
- Country/Region: Haryana,INDIA
- Product Name:Navitoclax-D8
- Products Intro:Brand:clearsynth | Product Number:CS-EC-00004
- Company Type: Trader
- Country/Region: Hyderabad,INDIA
- Product Name:ABT 263
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:ABT263
- Products Intro:Purity: 98% (Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:ABT 263
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Navitoclax
- Products Intro:Purity: As coa | Package: As request | CustNote: 923564-51-6
- Company Type: Trader
- Country/Region: CHINA
