ABT 737 manufacturers and suppliers in india

ABT 737

Properties

Melting point:: 152-154°C

Density: 1.38±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

form: Yellow solid

pka: 4.65±0.10(Predicted)

color: Light Yellow to Yellow

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

HS Code: 29309090

Use

ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with potential pro-apoptotic and antineoplastic activities, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice.