veratramine
veratramine
- CAS:
- 60-70-8
- MF:
- C27H39NO2
- MW:
- 409.6
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Properties
- Melting point:
- 122-1240C
- alpha
- D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol)
- Boiling point:
- 529.83°C (rough estimate)
- Density
- 1.0393 (rough estimate)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
- form
- solid
- pka
- 14.82±0.60(Predicted)
- color
- Tan
- λmax
- 268nm(lit.)
- Merck
- 14,9952
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301
- Precautionary statements
- P501-P270-P264-P301+P310+P330-P405
- RIDADR
- UN 2811 6.1/PG III
- RTECS
- YX5094000
- HS Code
- 2933.39.4100
- HazardClass
- 6.1
- PackingGroup
- III
Use
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer. Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM. Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.
1 India supplier list of "veratramine"
$8.00/ 1KG
- Product Name:veratramine
- Products Intro:Purity: >98% HPLC | Package: 1KG;8USD
- Company Type: Trader
- Country/Region: CHINA