Zolmitriptan
Zolmitriptan
- CAS:
- 139264-17-8
- MF:
- C16H21N3O2
- MW:
- 287.36
Suppliers by country/region
Company Type
Properties
- Melting point:
- 136-141°C
- alpha
- D22 -5.79° (c = 0.5 in methanol)
- Boiling point:
- 563.3±38.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- storage temp.
- 15-25°C
- solubility
- Soluble in DMSO at 5mg/ml
- pka
- 9.64(at 25℃)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -3 to -8°, c = 1 in methanol
- λmax
- 225nm(lit.)
- Merck
- 14,10189
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312+P330-P501
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- RQ2707000
- HS Code
- 29349990
- Toxicity
- women,TDLo,oral,6mg/kg/43W-I (6mg/kg),BEHAVIORAL: HEADACHE,Lancet. Vol. 353, Pg. 378, 1999.
Use
Zolmitriptan, the second triptan marketed (approved in1997), has a much better bioavailability (40%–48%) thansumatriptan. It is rapidly absorbed after oral or nasal sprayadministration. It also has an orally disintegrating tablet formulation(Zomig ZMT), which can be taken without water.Zolmitriptan undergoes rapid N-demethylation via CYP1A2to a more potent, active metabolite, N-desmethylzolmitriptan,which is 2 to 6 times more potent than the parentdrug. This active metabolite was detected 5 minutesafter dosing and accounts for about two thirds of the plasmaconcentration of the administered dose of the parent drug.284Thus, it is reasonable to assume that the therapeutic effectsand especially the CNS side effects of zolmitriptan must bein part attributed to the plasma levels of this active metabolite,at least until it is further degraded by hepatic MAO-Ato its inactive indole acetic acid derivatives.
45 India supplier list of "Zolmitriptan"
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and MT
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan Standard
- Products Intro:Purity: 97% | Package: 103 mg,500mg, 1 kg, and 10 kg
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:Zolmitriptan
- Company Type: Manufacturer
- Country/Region: INDIA