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1-Boc-3-(cyanomethylene)azetidine

1-Boc-3-(cyanomethylene)azetidine Structure
  • ₹3100 - ₹7400
  • Product name: 1-Boc-3-(cyanomethylene)azetidine
  • CAS: 1153949-11-1
  • MF: C10H14N2O2
  • MW: 194.23
  • EINECS:
  • MDL Number:MFCD12761241
  • Synonyms:1-Boc-3-(cyanomethylene)azetidine;tert-butyl 3-(cyanoMethylidene)azetidine-1-carboxylate;3-(Cyanomethylene)-1-azetidinecarboxylic acid tert-butyl ester;1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine;P-Hydroxy phenyl butanone (Raspberry ketone);tert-Butyl 3-(cyanomethylene);1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine;1-Azetidinecarboxylic acid, 3-(cyanomethylene)-, 1,1-dimethylethyl ester
2 prices
Selected condition:

Brand

  • TCI Chemicals (India)

Package

  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberB5217
  • Product description1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine min. 95.0 %
  • Packaging200MG
  • Price₹3100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB5217
  • Product description1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine min. 95.0 %
  • Packaging1G
  • Price₹7400
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B5217 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine min. 95.0 % 200MG ₹3100 2022-05-26 Buy
TCI Chemicals (India) B5217 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine min. 95.0 % 1G ₹7400 2022-05-26 Buy

Properties

Boiling point :309.7±35.0 °C(Predicted)
Density :1.215
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
form :powder to crystal
pka :-1.88±0.20(Predicted)
color :White to Orange to Green

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

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