Baricitinib
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- Product name: Baricitinib
- CAS: 1187594-09-7
- MF: C16H17N7O2S
- MW: 371.42
- EINECS:691-421-4
- MDL Number:MFCD21608464
- Synonyms:1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile;Baricitinib;INCB 028050;LY 3009104;BARICITINIB;INCB28050;LY3009104;Baricitinib (LY3009104);2-(3-(4-(3H-Pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile;Baricitinib/INCB 028050/LY3009104
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Properties
Melting point :212-215°C
Density :1.56
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
pka :11.66±0.50(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChIKey :XUZMWHLSFXCVMG-UHFFFAOYSA-N
SMILES :N1(S(CC)(=O)=O)CC(N2C=C(C3N=CN=C4NC=CC4=3)C=N2)(CC#N)C1
Density :1.56
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
pka :11.66±0.50(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChIKey :XUZMWHLSFXCVMG-UHFFFAOYSA-N
SMILES :N1(S(CC)(=O)=O)CC(N2C=C(C3N=CN=C4NC=CC4=3)C=N2)(CC#N)C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family. Baricitinib is an orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers. It has potential application in various inflammatory disorders, including rheumatoid arthritis.More related product prices
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