Cabazitaxel
![]() |
- ₹7815.65 - ₹31587.35
- Product name: Cabazitaxel
- CAS: 183133-96-2
- MF: C45H57NO14
- MW: 835.93
- EINECS:680-632-7
- MDL Number:MFCD18827611
- Synonyms:(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2487
- Product descriptionCabazitaxel ≥95% (HPLC)
- Packaging5MG
- Price₹7815.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2487
- Product descriptionCabazitaxel ≥95% (HPLC)
- Packaging25MG
- Price₹31587.35
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML2487 | Cabazitaxel ≥95% (HPLC) | 5MG | ₹7815.65 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML2487 | Cabazitaxel ≥95% (HPLC) | 25MG | ₹31587.35 | 2022-06-14 | Buy |
Properties
Melting point :180 °C
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Safety Information
Symbol(GHS): |
![]() ![]() |
|||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .
More related product prices
Afatinib (BIBW 2992) Erlotinib hydrochloride Alisertib (MLN8237) Imatinib Ceritinib (LDK378) (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Paclitaxel 10-Deacetylbaccatin III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid 7-O-(TRIETHYLSILYL) BACCATIN III Deacetyltaxol 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III Diethyl RivastigMine Docetaxel 139306-10-8Related product price
- Imatinib
₹5100-26800 - Paclitaxel
₹549-168790.01 - 10-Deacetylbaccatin III
₹7500-20545.85
Suppliers and manufacturers
Dr. Reddy's Laboratories Ltd
J S LABS
Hetero Drugs Limited
Shilpa Medicare Limited (SML)
Basil Drugs AND Pharmaceuticals Pvt Ltd
BDR Pharmaceuticals International Pvt Ltd
Shreyaa Medilife Private Limited
Vijaya Pharma And Life Science
Triveni Interchem Private Limited (Group Of Triveni...
PAN DRUGS LTD.