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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Standard Substance >1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Structure
  • ₹0
  • Product name: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
  • CAS: 1267610-26-3
  • MF: C15H19N3O2
  • MW: 273.33
  • EINECS:125-745-3
  • MDL Number:MFCD22581648
  • Synonyms:1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone;2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-;Apixaba inretMediate A;Apixaban Impurity S;Apixaban Impurity 47;Apixaban intA;Apixaban related impurities 2;Apixaban Impurity 50
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>246°C (dec.)
Boiling point :491.5±45.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :Solid
pka :4.96±0.10(Predicted)
color :Off-White to Pale Beige
InChI :InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey :YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES :C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

1-?(4-?Aminophenyl)?-?5,?6-?dihydro-?3-?(4-?morpholinyl)?-?2(1H)?-?pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

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38560-30-4 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE Apixaban ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE

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Suppliers and manufacturers

BTC pharm India COREY ORGANICS PVT LTD OPULENT PHARMA VGS SYNTHESIS PRIVATE LIMITED CVR Life sciences Pvt Ltd Aarti Industries Limited (AIL) Riddhesh Pharmachem Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) ABINTIO BIOSCIENCES Sekhment pharmaventures